Replication protein E1

spinqualitylabelsall models Bovine papillomavirus 1 replication protein E1 complex with DNA (PDB code 1ksx) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Replication protein E1 (RPE1) is a human papillomavirus (HPV) essential protein which is required for its replication. RPE1 recognizes the HPV origin of replication (ori) with the aid of regulatory protein E2 (RPE2). The resultant helicase complex initiates DNA unwinding to provide the template of progeny DNA synthesis, The HPV ori contains one RPE1 binding site and 2 RPE2 binding sites. RPE2 is found also in bovine papillomavirus (BPV). Disease RPE2 induces apoptosis of its host cells. Structural highlights The complex between HPV6a DBD and 18-bp DNA (PDB code 2ayg) shows the binding of 2 recognition helices of the dimer to 2 successive major grooves of the target DNA making numerous contacts to the DNA backbone phosphate atoms and to its bases.

3D structures of replication protein E1

Updated on 27-January-2021

Domains: helicase 301-605; DNA-binding (DBD) 286-365

2ayg - RPE1 DBD - HPV18
1tue - RPE1 428-631 (mutant) + RPE2 TAD
2v9p - RPE1 helicase domain - BPV1
5a9k - RPE1 helicase domain - Cryo EM
2gxa - RPE1 helicase domain + DNA + ADP
1f08 - RPE1 DBD
1ksx, 1ksy - RPE1 DBD + DNA

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky