Ubiquitin-fold modifier

spinqualitylabelsall models Human ubiquitin-fold modifier (pink, yellow) complex with ubiquitin-like modifier activating enzyme (green, grey) (PDB code 5iaa Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Ubiquitin-fold modifier (Ufm1) is a member of the ubiquitin-like family. Ufm1 is covalently attached to Lys residues of substrate proteins. This attachment is called Ufmylation and requires Ubiquitin-like modifier activating enzyme (UBA5) and Ufm1-conjugating enzyme (Ufc1). Ufmylation is a type of post-translational modification that deals with fine-tuned and complex cellular activities and is involved in reticulophagy induced by ER stress. Ufmylation is aribosomal modification specialized to facilitate metazoan-specific protein biogenesis at the ER. Relevance Ufm1 participates in maintenance of homeostasis and protection from inflammatory disease. Structural highlights The 3D structure of the complex between Ufm1 and UBA5 shows the Ufm1 critical binding sequence and the interactions between the 2 modifying enzymes.

3D Structures of Ubiquitin-fold modifier

Updated on 03-February-2021

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• Ubiquitin-fold modifier
  • 5ia7 – hUfm1 - human
    
  • 1wxs – hUfm1 - NMR
    
  • 5hkh – hUfm1 + peptide
    
  • 5iaa – hUfm1 + UBA5
    
  • 5l95 – hUfm1 + UBA5 + AMP
    
  • 6h77 – hUfm1 + UBA5 + ATP
    
  • 5xda – Ufm1 + Umf1-specific protease - Caenorhabditis elegans
    
  • 6izg – Ufm1 - Trypanosoma brucei - NMR
    
• Umf1-conjugating enzyme
  • 2z6o, 2z6p, 3evx – hUfc1
    
  • 2k07 – hUfc1 - NMR
    
• Ubiquitin-like modifier activating enzyme
  • 3h8v, 6h78 – hUBA5 + ATP
    
  • 3guc – hUBA5 + AMPPNP
    

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Michal Harel, Alexander Berchansky