2eav: Difference between revisions
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==Crystal structure of the C-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein Ibeta== | ==Crystal structure of the C-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein Ibeta== | ||
<StructureSection load='2eav' size='340' side='right' caption='[[2eav]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='2eav' size='340' side='right'caption='[[2eav]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2eav]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2eav]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EAV FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2eax|2eax]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2eax|2eax]]</div></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PGRPIB ([ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PGRPIB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eav OCA], [https://pdbe.org/2eav PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eav RCSB], [https://www.ebi.ac.uk/pdbsum/2eav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eav ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/PGRP4_HUMAN PGRP4_HUMAN]] Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.<ref>PMID:16354652</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 35: | Line 35: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Cho, S]] | [[Category: Cho, S]] | ||
[[Category: Mariuzza, R A]] | [[Category: Mariuzza, R A]] | ||
[[Category: Alpha/beta mix]] | [[Category: Alpha/beta mix]] | ||
[[Category: Sugar binding protein]] | [[Category: Sugar binding protein]] | ||
