2ej8: Difference between revisions
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==Crystal structure of APPL1 PTB domain at 1.8A== | ==Crystal structure of APPL1 PTB domain at 1.8A== | ||
<StructureSection load='2ej8' size='340' side='right' caption='[[2ej8]], [[Resolution|resolution]] 1.84Å' scene=''> | <StructureSection load='2ej8' size='340' side='right'caption='[[2ej8]], [[Resolution|resolution]] 1.84Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ej8]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2ej8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EJ8 FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">APPL1 ([ | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">APPL1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ej8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ej8 OCA], [https://pdbe.org/2ej8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ej8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ej8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ej8 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ej8 TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/DP13A_HUMAN DP13A_HUMAN]] Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.<ref>PMID:10490823</ref> <ref>PMID:15016378</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Hosaka, T]] | [[Category: Hosaka, T]] | ||
[[Category: Murayama, K]] | [[Category: Murayama, K]] | ||
Revision as of 12:09, 10 February 2021
Crystal structure of APPL1 PTB domain at 1.8A
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