Sandbox Reserved 1660: Difference between revisions
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{{Sandbox_Reserved_ESBS20_}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_Reserved_ESBS20_}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
<StructureSection load='3GMQ' size='350' 'frame'='true' side='right' caption='Structure of mouse CD1d expressed in SF9 cells, no ligand added (PDB entry : [https://www.rcsb.org/structure/3GMQ 3GMQ])' scene='86/868193/Cd1d/ | <StructureSection load='3GMQ' size='350' 'frame'='true' side='right' caption='Structure of mouse CD1d expressed in SF9 cells, no ligand added (PDB entry : [https://www.rcsb.org/structure/3GMQ 3GMQ])' scene='86/868193/Cd1d/3'> | ||
=='''Structure of mouse CD1d'''== | =='''Structure of mouse CD1d'''== | ||
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NTK cells are a subset of [https://en.wikipedia.org/wiki/T_cell T cells] (which play a central role in the immune response) that are activated by CD1d-glycolipid complexes. α-GalCer is a potent NKT cell agonist when presented by CD1d. The stability of the CD1d-glycolipid complexes has an impact on the [https://en.wikipedia.org/wiki/Cytokine cytokine] release (cell signaling). Conformational variations that would stabilize the F’-pocket (primary site of interaction with the T cell receptor, NKT TCR) might increase CD1d affinity for the NKT TCR<ref name="affinity"/><ref name="site"/>. | NTK cells are a subset of [https://en.wikipedia.org/wiki/T_cell T cells] (which play a central role in the immune response) that are activated by CD1d-glycolipid complexes. α-GalCer is a potent NKT cell agonist when presented by CD1d. The stability of the CD1d-glycolipid complexes has an impact on the [https://en.wikipedia.org/wiki/Cytokine cytokine] release (cell signaling). Conformational variations that would stabilize the F’-pocket (primary site of interaction with the T cell receptor, NKT TCR) might increase CD1d affinity for the NKT TCR<ref name="affinity"/><ref name="site"/>. | ||
</p> | </p> | ||
<scene name='86/868193/ | <scene name='86/868193/Conformational_variations/1'>Conformational variations</scene> between CD1d no ligand and structure of bovine CD1d with bound C12-di-sulfatide. | ||
==== CD1d affinity ==== | ==== CD1d affinity ==== | ||
