2f2f: Difference between revisions

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==Crystal structure of cytolethal distending toxin (CDT) from Actinobacillus actinomycetemcomitans==
==Crystal structure of cytolethal distending toxin (CDT) from Actinobacillus actinomycetemcomitans==
<StructureSection load='2f2f' size='340' side='right' caption='[[2f2f]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='2f2f' size='340' side='right'caption='[[2f2f]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2f2f]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_acetinomycetum_comitans"_(sic)_(klinger_1912)_colebrook_1920 "bacterium acetinomycetum comitans" (sic) (klinger 1912) colebrook 1920]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F2F FirstGlance]. <br>
<table><tr><td colspan='2'>[[2f2f]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacterium_acetinomycetum_comitans"_(sic)_(klinger_1912)_colebrook_1920 "bacterium acetinomycetum comitans" (sic) (klinger 1912) colebrook 1920]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F2F FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cdtA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920]), cdtB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920]), cdtC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920])</td></tr>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cdtA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920]), cdtB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920]), cdtC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2f OCA], [http://pdbe.org/2f2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f2f RCSB], [http://www.ebi.ac.uk/pdbsum/2f2f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2f2f ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2f OCA], [https://pdbe.org/2f2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f2f RCSB], [https://www.ebi.ac.uk/pdbsum/2f2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f2f ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CDTA_AGGAC CDTA_AGGAC]] CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells.<ref>PMID:16434747</ref>   
[[https://www.uniprot.org/uniprot/CDTA_AGGAC CDTA_AGGAC]] CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells.<ref>PMID:16434747</ref>   
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/2f2f_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/2f2f_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Komoto, J]]
[[Category: Komoto, J]]
[[Category: Konishi, K]]
[[Category: Konishi, K]]
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