AlphaFold2 examples from CASP 14: Difference between revisions
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The quality of predictions for the structure of ORF8 are judged by comparison with X-ray crystallographic [[empirical models]] which were not available to the groups making predictions. Shortly after the CASP 14 competition (summer 2020), two X-ray crystal structures were reported for ORF8: [[7jtl]] released August 26, 2020, and [[7jx6]], released September 23, 2020. The [[resolution|resolutions]] are 2.0 and 1.6 Å respectively, and both have worse than average [[Rfree]] values. | The quality of predictions for the structure of ORF8 are judged by comparison with X-ray crystallographic [[empirical models]] which were not available to the groups making predictions. Shortly after the CASP 14 competition (summer 2020), two X-ray crystal structures were reported for ORF8: [[7jtl]] released August 26, 2020, and [[7jx6]], released September 23, 2020. The [[resolution|resolutions]] are 2.0 and 1.6 Å respectively, and both have worse than average [[Rfree]] values. | ||
The two X-ray structures agree very well: 87 of the 104 residues/chain align with a [https://en.wikipedia.org/wiki/Root-mean-square_deviation_of_atomic_positions root mean square deviation] '''(RMSD) of 0.66 Å'''<ref>Alignment and RMSD calculation was by ''iterative magic fit'' of Swiss PDB Viewer.</ref>. | |||
===AlphaFold2 Prediction for ORF8=== | ===AlphaFold2 Prediction for ORF8=== | ||
