1br9: Difference between revisions

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<StructureSection load='1br9' size='340' side='right'caption='[[1br9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='1br9' size='340' side='right'caption='[[1br9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1br9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BR9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1br9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BR9 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1br9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1br9 OCA], [http://pdbe.org/1br9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1br9 RCSB], [http://www.ebi.ac.uk/pdbsum/1br9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1br9 ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1br9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1br9 OCA], [https://pdbe.org/1br9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1br9 RCSB], [https://www.ebi.ac.uk/pdbsum/1br9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1br9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TIMP2_HUMAN TIMP2_HUMAN]] Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.<ref>PMID:2793861</ref> <ref>PMID:2554304</ref> <ref>PMID:11710594</ref>   
[[https://www.uniprot.org/uniprot/TIMP2_HUMAN TIMP2_HUMAN]] Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.<ref>PMID:2793861</ref> <ref>PMID:2554304</ref> <ref>PMID:11710594</ref>   
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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