PROTAC: Difference between revisions
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PROTAC ( | PROTAC (proteolysis-targeting chimera) is a small protein with two active domains joined by a linker. | ||
[[Image:PROTAC_70.png|thumb|right|300px|Representative PROTAC from [https://protacpedia.weizmann.ac.il/ptcb/detp?i=70 PROTACpedia] targeting EGFR Epidermal growth factor receptor P00533. <span class="bg-lightblue"><b>target binding ligand</b></span><span class="bg-lightmagenta"><b>linker</b></span><span class="bg-lightgreen"><b>E3 binder</b></span>]] | [[Image:PROTAC_70.png|thumb|right|300px|Representative PROTAC from [https://protacpedia.weizmann.ac.il/ptcb/detp?i=70 PROTACpedia] targeting EGFR Epidermal growth factor receptor P00533. <span class="bg-lightblue"><b>target binding ligand</b></span><span class="bg-lightmagenta"><b>linker</b></span><span class="bg-lightgreen"><b>E3 binder</b></span>]] | ||
==Predicting PROTACs== | |||
PRosettaC <ref>PRosettaC https://prosettac.weizmann.ac.il</ref> is a computational protocol for the prediction of PROTAC-induced ternary complexes <ref>pmid 32976709</ref>. The protocol receives as input, two protein structures (protein target and E3 ligase), including their appropriate ligands (binders), as well as the PROTAC chemical structure in a SMILES representation, and outputs predicted models for the ternary complex. | |||
== References == | == References == | ||
<references/> | <references/> | ||
