PROTAC

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D A Proteolysis-Targeting Chimera (PROTAC) is a small protein with two active domains joined by a linker. PROTACs represent an alternative to conventional enzyme inhibitors, by enabling proteasome induced degradation of the target protein . PROTAC Target Structure BRAF kinase domain 6uuo BRD9 bromodomain 6hm0 Cereblon 6r0q, 6r0u, 6r0v, 6r11, 6r12, 6r13, 6r18, 6r19, 6r1a, 6r1c, 6r1d, 6r1k, 6r1w, 6r1x DDB1-CRBN-BRD4(BD1) 6bn7, 6bn8, 6bn9, 6bnb, 6boy SMARCA2, SMARCA4 6hr2 Predicting PROTAC-induced ternary complexes PRosettaC is a computational resource for the prediction of PROTAC-induced ternary complexes . PRosettaC receives as input, two protein structures (protein target and E3 ligase), including their appropriate ligands (binders), as well as the PROTAC chemical structure in a SMILES representation, and outputs predicted models for the ternary complex. Other methods become available . PROTACpedia Representative PROTAC from PROTACpedia targeting EGFR Epidermal growth factor receptor P00533. target binding ligandlinkerE3 binder PROTACpedia is a collaborative and comprehensive, high-quality and freely accessible resource of manually curated data on Proteolysis Targeting Chimeras (PROTACs). The search can be performed by various parameters such as Target name, UniProt ID, SMILES substructure or by various details regarding a publication.

Proteopedia Page Contributors and Editors (what is this?)

Jaime Prilusky