6y3l: Difference between revisions
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==NMR solution structure of the hazelnut allergen Cor a 1.0404== | ==NMR solution structure of the hazelnut allergen Cor a 1.0404== | ||
<StructureSection load='6y3l' size='340' side='right'caption='[[6y3l]]' scene=''> | <StructureSection load='6y3l' size='340' side='right'caption='[[6y3l]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full | <table><tr><td colspan='2'>[[6y3l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Corav Corav]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y3L FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y3l OCA], [https://pdbe.org/6y3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y3l RCSB], [https://www.ebi.ac.uk/pdbsum/6y3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y3l ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y3l OCA], [https://pdbe.org/6y3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y3l RCSB], [https://www.ebi.ac.uk/pdbsum/6y3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y3l ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
A major proportion of allergic reactions to hazelnuts (Corylus avellana) are caused by immunologic cross-reactivity of IgE antibodies to pathogenesis-related class 10 (PR-10) proteins. Intriguingly, the four known isoforms of the hazelnut PR-10 allergen Cor a 1, denoted as Cor a 1.0401-Cor a 1.0404, share sequence identities exceeding 97% but possess different immunologic properties. In this work we describe the NMR solution structures of these proteins and provide an in-depth study of their biophysical properties. Despite sharing highly similar three-dimensional structures, the four isoforms exhibit remarkable differences regarding structural flexibility, hydrogen bonding and thermal stability. Our experimental data reveal an inverse relation between structural flexibility and IgE-binding in ELISA experiments, with the most flexible isoform having the lowest IgE-binding potential, while the isoform with the most rigid backbone scaffold displays the highest immunologic reactivity. These results point towards a significant entropic contribution to the process of antibody binding. | |||
Inverse relation between structural flexibility and IgE reactivity of Cor a 1 hazelnut allergens.,Fuhrer S, Kamenik AS, Zeindl R, Nothegger B, Hofer F, Reider N, Liedl KR, Tollinger M Sci Rep. 2021 Feb 18;11(1):4173. doi: 10.1038/s41598-021-83705-z. PMID:33603065<ref>PMID:33603065</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6y3l" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Corav]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Fuehrer S]] | [[Category: Fuehrer, S]] | ||
[[Category: Hofer F]] | [[Category: Hofer, F]] | ||
[[Category: Kamenik | [[Category: Kamenik, A S]] | ||
[[Category: Liedl | [[Category: Liedl, K R]] | ||
[[Category: Nothegger B]] | [[Category: Nothegger, B]] | ||
[[Category: Reider N]] | [[Category: Reider, N]] | ||
[[Category: Tollinger M]] | [[Category: Tollinger, M]] | ||
[[Category: Zeindl R]] | [[Category: Zeindl, R]] | ||
[[Category: Allergen]] | |||
[[Category: Bet v 1 cross-reactive protein]] | |||
[[Category: Hazelnut allergen]] | |||
[[Category: Pr-10 protein]] | |||
