AlphaFold2 examples from CASP 14: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Eric Martz (talk | contribs) No edit summary |
Eric Martz (talk | contribs) No edit summary |
||
| Line 85: | Line 85: | ||
<scene name='87/875686/T1037_length_404/1'>The X-ray structure of CASP 14 domain T1037</scene> (length 404 residues) consists of residues 337-369 + 531-901 of [[6vr4]] (taken from chain B). It is an <scene name='87/875686/T1037_length_404/2'>alpha/beta domain with secondary structure</scene> <span style="color:#ff0080;font-weight:bold;">45% helices</span>, <span style="color:#ffc800;background-color:black;font-weight:bold;"> 19% beta strands </span>, and 37% loops and turns. The N- and C-termini are 10 Å apart, and there are no cysteines (thus no disulfide bonds). | <scene name='87/875686/T1037_length_404/1'>The X-ray structure of CASP 14 domain T1037</scene> (length 404 residues) consists of residues 337-369 + 531-901 of [[6vr4]] (taken from chain B). It is an <scene name='87/875686/T1037_length_404/2'>alpha/beta domain with secondary structure</scene> <span style="color:#ff0080;font-weight:bold;">45% helices</span>, <span style="color:#ffc800;background-color:black;font-weight:bold;"> 19% beta strands </span>, and 37% loops and turns. The N- and C-termini are 10 Å apart, and there are no cysteines (thus no disulfide bonds). | ||
===T1037 contains several known | ===T1037 contains several known fold fragments=== | ||
(analysis in progress) | (Dali analysis in progress, to be added here) | ||
The [https://fatcat.godziklab.org/ FATCAT Server] reported that in order to superpose 150 residues (37% of 404) of T1037 with the closest structure in the PDB, 3 twists at hinges were required, after which an RMSD of 3.1 Å was achieved. For a 200-residue superposition (50% of 404), the best results after 3 twists had an RMSD of 5.4 Å. | |||
===AlphaFold2 prediction for T1037=== | ===AlphaFold2 prediction for T1037=== | ||
