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==Crystal structure of the complex between OX40L and OX40==
==Crystal structure of the complex between OX40L and OX40==
<StructureSection load='2hev' size='340' side='right' caption='[[2hev]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
<StructureSection load='2hev' size='340' side='right'caption='[[2hev]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2hev]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HEV FirstGlance]. <br>
<table><tr><td colspan='2'>[[2hev]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HEV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2hew|2hew]], [[2hey|2hey]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hew|2hew]], [[2hey|2hey]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFSF4, TXGP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), TNFRSF4, TXGP1L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFSF4, TXGP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), TNFRSF4, TXGP1L ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hev OCA], [http://pdbe.org/2hev PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hev RCSB], [http://www.ebi.ac.uk/pdbsum/2hev PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2hev ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hev OCA], [https://pdbe.org/2hev PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hev RCSB], [https://www.ebi.ac.uk/pdbsum/2hev PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hev ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/TNFL4_HUMAN TNFL4_HUMAN]] Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE) [MIM:[http://omim.org/entry/152700 152700]]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Note=The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance.<ref>PMID:18059267</ref>   
[[https://www.uniprot.org/uniprot/TNFL4_HUMAN TNFL4_HUMAN]] Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE) [MIM:[https://omim.org/entry/152700 152700]]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Note=The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance.<ref>PMID:18059267</ref>   
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TNFL4_HUMAN TNFL4_HUMAN]] Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. [[http://www.uniprot.org/uniprot/TNR4_HUMAN TNR4_HUMAN]] Receptor for TNFSF4/OX40L/GP34.  
[[https://www.uniprot.org/uniprot/TNFL4_HUMAN TNFL4_HUMAN]] Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. [[https://www.uniprot.org/uniprot/TNR4_HUMAN TNR4_HUMAN]] Receptor for TNFSF4/OX40L/GP34.  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Tumor necrosis factor receptor|Tumor necrosis factor receptor]]
*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Compaan, D M]]
[[Category: Compaan, D M]]
[[Category: Hymowitz, S G]]
[[Category: Hymowitz, S G]]
Retrieved from "https://proteopedia.org/2hev"