6fjo: Difference between revisions

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<StructureSection load='6fjo' size='340' side='right'caption='[[6fjo]], [[Resolution|resolution]] 1.17&Aring;' scene=''>
<StructureSection load='6fjo' size='340' side='right'caption='[[6fjo]], [[Resolution|resolution]] 1.17&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6fjo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Adenovirus_serotype_26 Adenovirus serotype 26]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FJO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FJO FirstGlance]. <br>
<table><tr><td colspan='2'>[[6fjo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Adenovirus_serotype_26 Adenovirus serotype 26]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FJO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6fjn|6fjn]], [[6fjp|6fjp]], [[6fjq|6fjq]], [[6hcn|6hcn]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6fjn|6fjn]], [[6fjp|6fjp]], [[6fjq|6fjq]], [[6hcn|6hcn]]</div></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fjo OCA], [http://pdbe.org/6fjo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fjo RCSB], [http://www.ebi.ac.uk/pdbsum/6fjo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fjo ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fjo OCA], [https://pdbe.org/6fjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fjo RCSB], [https://www.ebi.ac.uk/pdbsum/6fjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fjo ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Adenoviruses are clinically important agents. They cause respiratory distress, gastroenteritis, and epidemic keratoconjunctivitis. As non-enveloped, double-stranded DNA viruses, they are easily manipulated, making them popular vectors for therapeutic applications, including vaccines. Species D adenovirus type 26 (HAdV-D26) is both a cause of EKC and other diseases and a promising vaccine vector. HAdV-D26-derived vaccines are under investigation as protective platforms against HIV, Zika, and respiratory syncytial virus infections and are in phase 3 clinical trials for Ebola. We recently demonstrated that HAdV-D26 does not use CD46 or Desmoglein-2 as entry receptors, while the putative interaction with coxsackie and adenovirus receptor is low affinity and unlikely to represent the primary cell receptor. Here, we establish sialic acid as a primary entry receptor used by HAdV-D26. We demonstrate that removal of cell surface sialic acid inhibits HAdV-D26 infection, and provide a high-resolution crystal structure of HAdV-D26 fiber-knob in complex with sialic acid.
Human adenovirus type 26 uses sialic acid-bearing glycans as a primary cell entry receptor.,Baker AT, Mundy RM, Davies JA, Rizkallah PJ, Parker AL Sci Adv. 2019 Sep 4;5(9):eaax3567. doi: 10.1126/sciadv.aax3567. eCollection 2019 , Sep. PMID:31517055<ref>PMID:31517055</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6fjo" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
</StructureSection>
Retrieved from "https://proteopedia.org/6fjo"