2hwy: Difference between revisions
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==Structure of PIN domain of human SMG5.== | ==Structure of PIN domain of human SMG5.== | ||
<StructureSection load='2hwy' size='340' side='right' caption='[[2hwy]], [[Resolution|resolution]] 2.75Å' scene=''> | <StructureSection load='2hwy' size='340' side='right'caption='[[2hwy]], [[Resolution|resolution]] 2.75Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2hwy]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2hwy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HWY FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SMG5 ([ | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SMG5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hwy OCA], [https://pdbe.org/2hwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hwy RCSB], [https://www.ebi.ac.uk/pdbsum/2hwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hwy ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/SMG5_HUMAN SMG5_HUMAN]] Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity.<ref>PMID:17053788</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Behm-Ansmant, I]] | [[Category: Behm-Ansmant, I]] | ||
[[Category: Conti, E]] | [[Category: Conti, E]] | ||
