1a1m: Difference between revisions
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New page: left|200px<br /> <applet load="1a1m" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a1m, resolution 2.3Å" /> '''MHC CLASS I MOLECULE... |
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==Overview== | ==Overview== | ||
The structure of the human MHC class I molecule HLA-B53 complexed to two, nonameric peptide epitopes (from the malaria parasite P. falciparum and, the HIV2 gag protein) has been determined by X-ray crystallography at 2.3, angstrom resolution. The structures reveal the architecture of a, Pro-specific B pocket common to many HLA-B alleles. Relative to other, alleles, the B53 peptide-binding groove is widened by a significant (up to, 1.25 angstrom) shift in the position of the alpha 1 helix. Within this, groove, bound water molecules, acting in concert with the side chains of, polymorphic residues, provide the functional malleability of the MHC, which enables the high affinity/low specificity binding of multiple, peptide epitopes. | The structure of the human MHC class I molecule HLA-B53 complexed to two, nonameric peptide epitopes (from the malaria parasite P. falciparum and, the HIV2 gag protein) has been determined by X-ray crystallography at 2.3, angstrom resolution. The structures reveal the architecture of a, Pro-specific B pocket common to many HLA-B alleles. Relative to other, alleles, the B53 peptide-binding groove is widened by a significant (up to, 1.25 angstrom) shift in the position of the alpha 1 helix. Within this, groove, bound water molecules, acting in concert with the side chains of, polymorphic residues, provide the functional malleability of the MHC, which enables the high affinity/low specificity binding of multiple, peptide epitopes. | ||
==Disease== | |||
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142830 142830]], Hypoproteinemia, hypercatabolic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109700 109700]], Spondyloarthropathy, susceptibility to, 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142830 142830]], Stevens-Johnson syndrome, carbamazepine-induced, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142830 142830]] | |||
==About this Structure== | ==About this Structure== | ||
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[[Category: mhc]] | [[Category: mhc]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 15:54:18 2007'' | ||
