6w7l: Difference between revisions

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==Structure of Tdp1 catalytic domain in complex with inhibitor XZ632p==
==Structure of Tdp1 catalytic domain in complex with inhibitor XZ632p==
<StructureSection load='6w7l' size='340' side='right'caption='[[6w7l]]' scene=''>
<StructureSection load='6w7l' size='340' side='right'caption='[[6w7l]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6W7L FirstGlance]. <br>
<table><tr><td colspan='2'>[[6w7l]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6W7L FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w7l OCA], [https://pdbe.org/6w7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w7l RCSB], [https://www.ebi.ac.uk/pdbsum/6w7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w7l ProSAT]</span></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TGV:4-[(2-phenylimidazo[1,2-a]pyrazin-3-yl)amino]benzene-1,2-dicarboxylic+acid'>TGV</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w7l OCA], [https://pdbe.org/6w7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w7l RCSB], [https://www.ebi.ac.uk/pdbsum/6w7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w7l ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[https://www.uniprot.org/uniprot/TYDP1_HUMAN TYDP1_HUMAN]] Defects in TDP1 are the cause of spinocerebellar ataxia autosomal recessive with axonal neuropathy (SCAN1) [MIM:[https://omim.org/entry/607250 607250]]. SCAN1 is an autosomal recessive cerebellar ataxia (ARCA) associated with peripheral axonal motor and sensory neuropathy, distal muscular atrophy, pes cavus and steppage gait as seen in Charcot-Marie-Tooth neuropathy. All affected individuals have normal intelligence.<ref>PMID:16141202</ref> <ref>PMID:15647511</ref> <ref>PMID:12244316</ref> <ref>PMID:17948061</ref> <ref>PMID:15920477</ref> 
== Function ==
[[https://www.uniprot.org/uniprot/TYDP1_HUMAN TYDP1_HUMAN]] DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.<ref>PMID:12023295</ref> <ref>PMID:15111055</ref> <ref>PMID:15811850</ref> <ref>PMID:16141202</ref> <ref>PMID:22822062</ref> 
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Burke TR]]
[[Category: Burke, T R]]
[[Category: Kiselev E]]
[[Category: Kiselev, E]]
[[Category: Lountos GT]]
[[Category: Lountos, G T]]
[[Category: Needle D]]
[[Category: Needle, D]]
[[Category: Pommier Y]]
[[Category: Pommier, Y]]
[[Category: Tropea JE]]
[[Category: Tropea, J E]]
[[Category: Waugh DS]]
[[Category: Waugh, D S]]
[[Category: Zhao XZ]]
[[Category: Zhao, X Z]]
[[Category: Cancer drug target]]
[[Category: Dna binding protein]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Inhibitor]]
[[Category: Phosphodiesterase]]
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