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==Crystal structure of human prostacyclin synthase==
==Crystal structure of human prostacyclin synthase==
<StructureSection load='2iag' size='340' side='right' caption='[[2iag]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='2iag' size='340' side='right'caption='[[2iag]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2iag]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IAG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IAG FirstGlance]. <br>
<table><tr><td colspan='2'>[[2iag]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IAG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IAG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTGIS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTGIS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-I_synthase Prostaglandin-I synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.4 5.3.99.4] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Prostaglandin-I_synthase Prostaglandin-I synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.4 5.3.99.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iag OCA], [http://pdbe.org/2iag PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iag RCSB], [http://www.ebi.ac.uk/pdbsum/2iag PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2iag ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iag OCA], [https://pdbe.org/2iag PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iag RCSB], [https://www.ebi.ac.uk/pdbsum/2iag PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iag ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PTGIS_HUMAN PTGIS_HUMAN]] Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).  
[[https://www.uniprot.org/uniprot/PTGIS_HUMAN PTGIS_HUMAN]] Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Prostaglandin-I synthase]]
[[Category: Prostaglandin-I synthase]]
[[Category: Chan, N L]]
[[Category: Chan, N L]]
Retrieved from "https://proteopedia.org/2iag"