1e31: Difference between revisions
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'''SURVIVIN DIMER H. SAPIENS''' | '''SURVIVIN DIMER H. SAPIENS''' | ||
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[[Category: Margolis, R.]] | [[Category: Margolis, R.]] | ||
[[Category: Skoufias, D.]] | [[Category: Skoufias, D.]] | ||
[[Category: | [[Category: Apotosis]] | ||
[[Category: | [[Category: Iap]] | ||
[[Category: | [[Category: Zinc finger]] | ||
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Revision as of 11:35, 2 May 2008
SURVIVIN DIMER H. SAPIENS
Overview
Survivin is a mitotic spindle-associated protein involved in linking mitotic spindle function to activation of apoptosis in mammalian cells. The structure of the full-length human survivin has been determined by X-ray crystallography to 2.7 A. Strikingly, the structure forms a very unusual bow tie-shaped dimer. It does not dimerize through a C-terminal coiled-coil, contrary to sequence analysis prediction. The C-terminal helices contain hydrophobic clusters with the potential for protein-protein interactions. The unusual shape and dimensions of survivin suggest it serves an adaptor function through its alpha-helical extensions.
About this Structure
1E31 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions., Chantalat L, Skoufias DA, Kleman JP, Jung B, Dideberg O, Margolis RL, Mol Cell. 2000 Jul;6(1):183-9. PMID:10949039 Page seeded by OCA on Fri May 2 14:35:49 2008
