Receptor: Difference between revisions

Line 39:

*[[Binding site of AChR]]

*[[Acetylcholine Receptor and its Reaction to Cobra Venom]]

When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin binding to the receptor as an extracellular ligand by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. There must be five molecules of cobra toxin (red) to block the receptor (blue) as each molecule binds with an individual alpha chain on the acetylcholine receptor. This molecule was generated by overlaying the receptor and venom using Swiss PDB viewer magic fit. The RMS (root mean square difference) of this overlay if 12.21 angstroms involving 185 different atoms. The second image depicts an individual toxin binding with one chain on the receptor, both in the same color.

<scene name='77/778333/Cobra_snake_venom/3'>Cobra Venom Interaction with Acetylcholine Receptor</scene>

This representation shows each molecule of the <scene name='77/778333/Venom_receptor_piece/1'>Cobra toxin binding to one chain of the receptor</scene>.

*[[Molecular Playground/Glutamate Receptor|AMPA glutamate receptor]] by [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

*[[Glutamate receptor (GluA2)]]

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@@ Line 39: / Line 39: @@
 *[[Binding site of AChR]]
 *[[Acetylcholine Receptor and its Reaction to Cobra Venom]]
+When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin binding to the receptor as an extracellular ligand by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. There must be five molecules of cobra toxin (red) to block the receptor (blue) as each molecule binds with an individual alpha chain on the acetylcholine receptor. This molecule was generated by overlaying the receptor and venom using Swiss PDB viewer magic fit. The RMS (root mean square difference) of this overlay if 12.21 angstroms involving 185 different atoms. The second image depicts an individual toxin binding with one chain on the receptor, both in the same color.
+<scene name='77/778333/Cobra_snake_venom/3'>Cobra Venom Interaction with Acetylcholine Receptor</scene>
+This representation shows each molecule of the <scene name='77/778333/Venom_receptor_piece/1'>Cobra toxin binding to one chain of the receptor</scene>.
 *[[Molecular Playground/Glutamate Receptor|AMPA glutamate receptor]] by [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].
 *[[Glutamate receptor (GluA2)]]