Induced fit: Difference between revisions
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[[Image:Induced fit.gif|frame|Morph of hexokinase in the open [[3o8m]] and glucose-bound closed [[3o80]] conformation. For reference, glucose (purple) is shown throughout the morph. Two views are shown, an overview as spacefill and a detail of the binding site in wireframe.]] | |||
[[Induced fit]] describes a conformational change in a protein when it binds a ligand, in contrast to a lock-and-key model of ligand binding. A classical example of induced fit is binding of glucose to hexokinase, depicted in a morph between [[3o8m]] and [[3o80]] below. | [[Induced fit]] describes a conformational change in a protein when it binds a ligand, in contrast to a lock-and-key model of ligand binding. A classical example of induced fit is binding of glucose to hexokinase, depicted in a morph between [[3o8m]] and [[3o80]] below. | ||
==History of the concept== | ==History of the concept== | ||
