6qbv: Difference between revisions
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==Structure of the HTLV-2 integrase catalytic core domain in complex with magnesium (dimeric form)== | ==Structure of the HTLV-2 integrase catalytic core domain in complex with magnesium (dimeric form)== | ||
<StructureSection load='6qbv' size='340' side='right'caption='[[6qbv]]' scene=''> | <StructureSection load='6qbv' size='340' side='right'caption='[[6qbv]], [[Resolution|resolution]] 2.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QBV OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6qbv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Htlv-2 Htlv-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QBV FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6qbt|6qbt]]</div></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pol ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11909 HTLV-2])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qbv OCA], [https://pdbe.org/6qbv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qbv RCSB], [https://www.ebi.ac.uk/pdbsum/6qbv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qbv ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Human T-cell lymphotropic virus type 1 (HTLV-1) is a deltaretrovirus and the most oncogenic pathogen. Many of the ~20 million HTLV-1 infected people will develop severe leukaemia or an ALS-like motor disease, unless a therapy becomes available. A key step in the establishment of infection is the integration of viral genetic material into the host genome, catalysed by the retroviral integrase (IN) enzyme. Here, we use X-ray crystallography and single-particle cryo-electron microscopy to determine the structure of the functional deltaretroviral IN assembled on viral DNA ends and bound to the B56gamma subunit of its human host factor, protein phosphatase 2 A. The structure reveals a tetrameric IN assembly bound to two molecules of the phosphatase via a conserved short linear motif. Insight into the deltaretroviral intasome and its interaction with the host will be crucial for understanding the pattern of integration events in infected individuals and therefore bears important clinical implications. | |||
Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56gamma.,Barski MS, Minnell JJ, Hodakova Z, Pye VE, Nans A, Cherepanov P, Maertens GN Nat Commun. 2020 Oct 7;11(1):5043. doi: 10.1038/s41467-020-18874-y. PMID:33028863<ref>PMID:33028863</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6qbv" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Retroviral integrase 3D structures|Retroviral integrase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Htlv-2]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Barski | [[Category: Barski, M S]] | ||
[[Category: Maertens | [[Category: Maertens, G N]] | ||
[[Category: Deltaretrovirus]] | |||
[[Category: Integration]] | |||
[[Category: Nucleotidyltransferase]] | |||
[[Category: Retrovirus]] | |||
[[Category: Strand-transfer]] | |||
[[Category: Transferase]] | |||
Latest revision as of 06:51, 14 April 2021
Structure of the HTLV-2 integrase catalytic core domain in complex with magnesium (dimeric form)
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