2ksg: Difference between revisions
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==Solution structure of dermcidin-1L, a human antibiotic peptide== | ==Solution structure of dermcidin-1L, a human antibiotic peptide== | ||
<StructureSection load='2ksg' size='340' side='right' caption='[[2ksg]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2ksg' size='340' side='right'caption='[[2ksg]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ksg]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2ksg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KSG FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DCD, AIDD, DSEP ([ | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DCD, AIDD, DSEP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ksg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ksg OCA], [https://pdbe.org/2ksg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ksg RCSB], [https://www.ebi.ac.uk/pdbsum/2ksg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ksg ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/DCD_HUMAN DCD_HUMAN]] DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity.<ref>PMID:17448443</ref> Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.<ref>PMID:17448443</ref> | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Jung, H]] | [[Category: Jung, H]] | ||
[[Category: Kim, J]] | [[Category: Kim, J]] | ||
