Receptor: Difference between revisions
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*[[μ Opioid Receptors]] | *[[μ Opioid Receptors]] | ||
*[[Mu Opioid Receptor]] | *[[Mu Opioid Receptor]] | ||
In the case of the μ-opioid receptor, the binding of an opioid signaling molecule induces a <scene name='78/786661/Mor_on_off/2'>conformational change</scene> in the receptor that activates an inhibitory G-protein (Gαi/o). This results in the dissociation of the G-protein complex. The Gα subunit then inhibits adenylyl cyclase. The Gβγ subunit acts to inhibit Ca2+ channels while activing K+ channels. | In the case of the μ-opioid receptor, the binding of an opioid signaling molecule induces a <scene name='78/786661/Mor_on_off/2'>conformational change</scene> in the receptor that activates an inhibitory G-protein (Gαi/o). This results in the dissociation of the G-protein complex. The Gα subunit then inhibits adenylyl cyclase. The Gβγ subunit acts to inhibit Ca2+ channels while activing K+ channels. While much has been learned about μ-opioid receptors since their discovery in 1973, there is still much that is unknown about their structure and <scene name='87/874998/Mor_on_off/1'>activation mechanism</scene>. | ||
*[[Student Project 3 for UMass Chemistry 423 Spring 2015|The '''κ-opioid receptor''' binds opium-type ligands]]. | *[[Student Project 3 for UMass Chemistry 423 Spring 2015|The '''κ-opioid receptor''' binds opium-type ligands]]. | ||
