Sandbox Reserved 1674: Difference between revisions
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== Function of your protein == | == Function of your protein == | ||
<StructureSection load='7K2X' size='340' side='right' caption='Overall structure of CTX-M Beta-Lactamase without any important ligands. (PDB: 7K2X)' scene=''> | <StructureSection load='7K2X' size='340' side='right' caption='Overall structure of CTX-M Beta-Lactamase without any important ligands. (PDB: 7K2X)' scene=''> | ||
CTX-M Beta-Lactamase is an enzyme made to inhibit Beta-Lactam. It is found within bacteria, specifically the ''E. coli'' bacteria. Beta- Lactamase binds with <scene name='87/873236/Ampicillin/2'>ampicillin</scene> and <scene name='87/873236/Cefotaxime/ | CTX-M Beta-Lactamase is an enzyme made to inhibit Beta-Lactam. It is found within bacteria, specifically the ''E. coli'' bacteria. Beta- Lactamase binds with <scene name='87/873236/Ampicillin/2'>ampicillin</scene> and <scene name='87/873236/Cefotaxime/3'>cefotaxime</scene>, both of which are types of drugs made to fight bacterial infections. Beta-Lactamase specifically attacks the lactam ring within both of these structures using a deacylation. | ||
== Biological relevance and broader implications == | == Biological relevance and broader implications == | ||
This enzyme inhibits the drug's function by breaking apart the lactam ring. This is does cause drug resistance within the ''E. coli'' bacteria making it much harder to treat via drug therapies. | This enzyme inhibits the drug's function by breaking apart the lactam ring. This is does cause drug resistance within the ''E. coli'' bacteria making it much harder to treat via drug therapies. | ||
