6k6n: Difference between revisions
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<StructureSection load='6k6n' size='340' side='right'caption='[[6k6n]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='6k6n' size='340' side='right'caption='[[6k6n]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6k6n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K6N OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6k6n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Civ Civ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K6N FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">nef ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11723 CIV])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k6n OCA], [https://pdbe.org/6k6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k6n RCSB], [https://www.ebi.ac.uk/pdbsum/6k6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k6n ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The human immunodeficiency virus (HIV) accessory protein Nef plays a major role in establishing and maintaining infection, particularly through immune evasion. Many HIV-2-infected people experience long-term viral control and survival, resembling HIV-1 elite control. HIV-2 Nef has overlapping but also distinct functions from HIV-1 Nef. Here we report the crystal structure of HIV-2 Nef core. The di-leucine sorting motif forms a helix bound to neighboring molecules, and moreover, isothermal titration calorimetry demonstrated that the CD3 endocytosis motif can directly bind to HIV-2 Nef, ensuring AP-2-mediated endocytosis for CD3. The highly conserved C-terminal region forms a alpha-helix, absent from HIV-1. We further determined the structure of simian immunodeficiency virus (SIV) Nef harboring this region, demonstrating similar C-terminal alpha-helix, which may contribute to AP-1 binding for MHC-I downregulation. These results provide insights into the distinct pathogenesis of HIV-2 infection. | |||
Structure of HIV-2 Nef Reveals Features Distinct from HIV-1 Involved in Immune Regulation.,Hirao K, Andrews S, Kuroki K, Kusaka H, Tadokoro T, Kita S, Ose T, Rowland-Jones SL, Maenaka K iScience. 2020 Jan 24;23(1):100758. doi: 10.1016/j.isci.2019.100758. Epub 2019, Dec 9. PMID:31927483<ref>PMID:31927483</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6k6n" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Protein Nef|Protein Nef]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Civ]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Andrews, S]] | [[Category: Andrews, S]] | ||
Revision as of 08:27, 21 April 2021
Crystal structure of SIVmac239 Nef protein
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