1kmt: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[1kmt]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KMT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1KMT FirstGlance]. <br>

<table><tr><td colspan='2'>[[1kmt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KMT FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1kmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kmt OCA], [~~http~~://pdbe.org/1kmt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1kmt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1kmt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1kmt ProSAT]</span></td></tr>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kmt OCA], [https://pdbe.org/1kmt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kmt RCSB], [https://www.ebi.ac.uk/pdbsum/1kmt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kmt ProSAT]</span></td></tr>

</table>

== Function ==

[[~~http~~://www.uniprot.org/uniprot/GDIR1_HUMAN GDIR1_HUMAN]] Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity).

[[https://www.uniprot.org/uniprot/GDIR1_HUMAN GDIR1_HUMAN]] Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity).

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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 <StructureSection load='1kmt' size='340' side='right'caption='[[1kmt]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1kmt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KMT FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1kmt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KMT FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kmt OCA], [http://pdbe.org/1kmt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kmt RCSB], [http://www.ebi.ac.uk/pdbsum/1kmt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kmt ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kmt OCA], [https://pdbe.org/1kmt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kmt RCSB], [https://www.ebi.ac.uk/pdbsum/1kmt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kmt ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/GDIR1_HUMAN GDIR1_HUMAN]] Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity).
+[[https://www.uniprot.org/uniprot/GDIR1_HUMAN GDIR1_HUMAN]] Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]