Receptor: Difference between revisions

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When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin binding to the receptor as an extracellular ligand by interacting with OH group leaving the acetylcholine channel open which releases ions used in creating an action potential. There must be 5 molecules of cobra toxin (red) to block the receptor (blue) as each molecule binds with an individual alpha chain on the acetylcholine receptor. The 2nd image depicts an individual toxin binding with one chain on the receptor, both in the same color. <scene name='77/778333/Cobra_snake_venom/3'>Cobra Venom Interaction with Acetylcholine Receptor</scene>. This representation shows each molecule of the <scene name='77/778333/Venom_receptor_piece/1'>Cobra toxin binding to one chain of the receptor</scene>.
When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin binding to the receptor as an extracellular ligand by interacting with OH group leaving the acetylcholine channel open which releases ions used in creating an action potential. There must be 5 molecules of cobra toxin (red) to block the receptor (blue) as each molecule binds with an individual alpha chain on the acetylcholine receptor. The 2nd image depicts an individual toxin binding with one chain on the receptor, both in the same color. <scene name='77/778333/Cobra_snake_venom/3'>Cobra Venom Interaction with Acetylcholine Receptor</scene>. This representation shows each molecule of the <scene name='77/778333/Venom_receptor_piece/1'>Cobra toxin binding to one chain of the receptor</scene>.


*[[Molecular Playground/Glutamate Receptor|AMPA glutamate receptor]] by [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].
*[[Molecular Playground/Glutamate Receptor|AMPA glutamate receptor]]
Full view of the glutamate receptor shows the overall structure (N-terminal, ligand-binding and transmembrane domains) in both <scene name='User:Mariel_Feliciano/sandbox_1/Full_view_black_background/6'>ribbon</scene> and <scene name='User:Mariel_Feliciano/sandbox_1/Full_view_spacefill/2'>spacefilling</scene> models. <scene name='User:Mariel_Feliciano/sandbox_1/Amino_terminal_domains/2'>N-terminal domain</scene> is a part of the extracellular domain. This domain is implicated in receptor assembly, trafficking, and localization.  
Full view of the glutamate receptor shows the overall structure (N-terminal, ligand-binding and transmembrane domains) in <scene name='User:Mariel_Feliciano/sandbox_1/Full_view_black_background/6'>ribbon</scene> and <scene name='User:Mariel_Feliciano/sandbox_1/Full_view_spacefill/2'>spacefilling</scene> models. <scene name='User:Mariel_Feliciano/sandbox_1/Amino_terminal_domains/2'>N-terminal domain</scene> is a part of the extracellular domain. This domain is implicated in receptor assembly, trafficking, and localization.  
*<scene name='Molecular_Playground/Glutamate_Receptor/Transmembrane_domains/5'>Transmembrane Domain</scene>.
*<scene name='Molecular_Playground/Glutamate_Receptor/Transmembrane_domains/5'>Transmembrane Domain</scene>.
*<scene name='Molecular_Playground/Glutamate_Receptor/Transmembrane_domains_pore2/1'>Transmembrane Domain, other representaion</scene>. This domain widens in response to glutamate binding allowing for positive ions to pass through the post-synaptic membrane.  
*<scene name='Molecular_Playground/Glutamate_Receptor/Transmembrane_domains_pore2/1'>Transmembrane Domain, other representaion</scene>. This domain widens in response to glutamate binding allowing for positive ions to pass through the post-synaptic membrane.  
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