Postsynaptic density protein: Difference between revisions

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“The PSD-95 family of PDZ scaffold proteins is encoded by four genes (PSD-95/SAP90 (synapse-associated protein 90), PSD-93/chapsyn-110, SAP102 and SAP97). These proteins are characterized by three PDZ domains, an SRC homology 3 (SH3) domain, and a Guanylate Kinase-like (GK) domain (Kim & Sheng, 2004).” PSD-95 is comprised of three PDZ domains, an SRC Homology3 (SH3),  and a guanylate kinase-like (GK) domain. (Zhu, 2011)
“The PSD-95 family of PDZ scaffold proteins is encoded by four genes (PSD-95/SAP90 (synapse-associated protein 90), PSD-93/chapsyn-110, SAP102 and SAP97). These proteins are characterized by three PDZ domains, an SRC homology 3 (SH3) domain, and a Guanylate Kinase-like (GK) domain (Kim & Sheng, 2004).” PSD-95 is comprised of three PDZ domains, an SRC Homology3 (SH3),  and a guanylate kinase-like (GK) domain. (Zhu, 2011)


PDZ Domain: PDZ is a protein-interaction domain that can form large molecular structures by binding to other scaffolding proteins. The determining factor for a PDZ depends on the amino acid sequence of its ligands on their C terminal. The first two PDZ proteins in PSD-95 are arranged in a way such that they both have their C terminals capable of binding to their ligand from the same direction as the other.  The PDZ-1 and PDZ-2 domains that bind to the NMDA receptor (NMDAR), NR2 subunits, and Kv1 channels are positioned in similar orientations.  
PDZ Domain: PDZ is a protein-interaction domain that can form large molecular structures by binding to other scaffolding proteins. The determining factor for a PDZ depends on the amino acid sequence of its ligands on their C terminal. The first two PDZ proteins in PSD-95 are arranged in a way such that they both have their C terminals capable of binding to their ligand from the same direction as the other.  The PDZ-1 and PDZ-2 domains that bind to the NMDA receptor (NMDAR), NR2 subunits, and Kv1 channels are positioned in similar orientations. The third PDZ domain has its strongest interactions done by its C-terminal. Currently it is thought that an unbound PDZ-3 domain is waiting to interact with its C-terminal protein.
The third PDZ domain has its strongest interactions done by its C-terminal. Currently it is thought that an unbound PDZ-3 domain is waiting to interact with its C-terminal protein.


Src-Homolgy 3 (SH3): The SH3 or shank subunit is a small portion of PSD-95. This roughly 60 amino acid long molecule is an extremely common subunit that is found in almost all cells. In PSD-95 the subunit exists near the end, farthest away from the cell membrane. Here this subunit can bind to a multitude of proteins; the most common proteins that it binds in this position are the horizontal proteins GKAP and SAPAP. This subunit is also made of domains, one of which is capable of polymerizing itself form its regular round shape into one that is more reminiscent of a sheet.
Src-Homolgy 3 (SH3): The SH3 or shank subunit is a small portion of PSD-95. This roughly 60 amino acid long molecule is an extremely common subunit that is found in almost all cells. In PSD-95 the subunit exists near the end, farthest away from the cell membrane. Here this subunit can bind to a multitude of proteins; the most common proteins that it binds in this position are the horizontal proteins GKAP and SAPAP. This subunit is also made of domains, one of which is capable of polymerizing itself form its regular round shape into one that is more reminiscent of a sheet.
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