Sandbox GGC9: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 13: | Line 13: | ||
The subunit structure is defined as a homodimer. | The subunit structure is defined as a homodimer. | ||
The zinc site plays an important role in DNA cleavage; without the zinc site the DNA would not be able to be cleaved and would not form the essential hairpin structure. | The zinc site plays an important role in DNA cleavage; without the zinc site the DNA would not be able to be cleaved and would not form the essential hairpin structure.[5] | ||
<scene name='75/752271/Zinc_ligands/1'>Zinc Ligands</scene> | <scene name='75/752271/Zinc_ligands/1'>Zinc Ligands</scene> | ||
| Line 27: | Line 27: | ||
[4] Omenn syndrome | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program. Rarediseases.info.nih.gov. (2021). Retrieved 7 April 2021, from https://rarediseases.info.nih.gov/diseases/8198/omenn-syndrome. | [4] Omenn syndrome | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program. Rarediseases.info.nih.gov. (2021). Retrieved 7 April 2021, from https://rarediseases.info.nih.gov/diseases/8198/omenn-syndrome. | ||
[5] Gwyn, Lori M et al. “A zinc site in the C-terminal domain of RAG1 is essential for DNA cleavage activity.” Journal of molecular biology vol. 390,5 (2009): 863-78. doi:10.1016/j.jmb.2009.05.076 | |||
