Sandbox GGC16: Difference between revisions
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=== PEST domain === | === PEST domain === | ||
<scene name='87/874948/Pest/2'>PEST domain</scene> | <scene name='87/874948/Pest/2'>PEST domain</scene> | ||
The PEST domain is adjacent to the binding domain and has been found mutated in leukemia patients. It is highly polar due to the abundance of proline, glutamate, serine, and threonine. Proteins with a PEST region typically have a short half-life of under 2 hours. It is hypothesized that the PEST region is a tag for fast degradation of the protein. | The PEST domain is adjacent to the binding domain and has been found mutated in leukemia patients.<ref>Mueller, B. U. Heterozygous PU.1 Mutations Are Associated with Acute | ||
Myeloid Leukemia. Blood. 2003, 101(5), 2074–2074.</ref> It is highly polar due to the abundance of proline, glutamate, serine, and threonine. Proteins with a PEST region typically have a short half-life of under 2 hours. It is hypothesized that the PEST region is a tag for fast degradation of the protein. | |||
== Structural highlights == | == Structural highlights == | ||
