Sandbox GGC16: Difference between revisions

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	=== Activation ===		=== Activation ===

	A post-translational modification of PU.1 occurs at a serine residue (residue 41). This phosphorylation by protein kinase B (AKT) induces PU.1 activation.<ref>Rieske, P., & Pongubala, J. M. R. (2001). AKT Induces Transcriptional Activity of PU.1 through Phosphorylation-mediated Modifications within Its Transactivation Domain. Journal of Biological Chemistry, 276(11), 8460–8468. https://doi.org/10.1074/jbc.m007482200</ref>		A post-translational modification of PU.1 occurs at a serine residue (residue 41). This phosphorylation by protein kinase B (AKT) induces PU.1 activation.<ref>Rieske, P., & Pongubala, J. M. R. (2001). AKT Induces Transcriptional Activity of PU.1 through Phosphorylation-mediated Modifications within Its Transactivation Domain. Journal of Biological Chemistry, 276(11), 8460–8468. https://doi.org/10.1074/jbc.m007482200</ref>

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