Sandbox GGC15: Difference between revisions

Revision as of 20:29, 27 April 2021

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 ==DNA TOPOISOMERASE I==
 <StructureSection load='1A36' size='340' side='right' caption='Caption for this structure' scene=''>
-Eukaryotic DNA topoisomerase I (topo I) is a protein that reduces the strain from the supercoils that are caused during transcription and translation<ref>DOI 10.1073/pnas.242259599</ref>. There are two types of topoisomerases. Type 1 topoisomerases are monomeric and break one strand of DNA<ref>PMID:9488644</ref>. Type 2 topoisomerases are dimeric, meaning that they made up of two units and break both strands of the DNA helix<ref name="Staker et al., 2002">PMID:9488644</ref>. They are able to pass another part of the duplex through the cut, and close the cut using ATP<ref name="Staker et al., 2002" />.
+Eukaryotic DNA topoisomerase I (topo I) is a protein that reduces the strain from the supercoils that are caused during transcription and translation<ref name="Redinbo et al., 1998">DOI 10.1073/pnas.242259599</ref>. There are two types of topoisomerases. Type 1 topoisomerases are monomeric and break one strand of DNA<ref name="Staker et al., 2002">PMID:9488644</ref>. Type 2 topoisomerases are dimeric, meaning that they made up of two units and break both strands of the DNA helix<ref name="Staker et al., 2002" />. They are able to pass another part of the duplex through the cut, and close the cut using ATP<ref name="Staker et al., 2002" />.
 == Function ==