6xor: Difference between revisions
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==Structure of the Self-Association Domain of Swallow== | ==Structure of the Self-Association Domain of Swallow== | ||
<StructureSection load='6xor' size='340' side='right'caption='[[6xor]]' scene=''> | <StructureSection load='6xor' size='340' side='right'caption='[[6xor]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full | <table><tr><td colspan='2'>[[6xor]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XOR FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xor OCA], [https://pdbe.org/6xor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xor RCSB], [https://www.ebi.ac.uk/pdbsum/6xor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xor ProSAT]</span></td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3e2b|3e2b]]</div></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">swa, CG3429 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xor OCA], [https://pdbe.org/6xor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xor RCSB], [https://www.ebi.ac.uk/pdbsum/6xor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xor ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/SWA_DROME SWA_DROME]] Has a role in localizing bicoid mRNA at the anterior margin of the oocyte during oogenesis, and a poorly characterized role in nuclear divisions in early embryogenesis.<ref>PMID:1806330</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Swallow, a 62 kDa multidomain protein, is required for the proper localization of several mRNAs involved in the development of Drosophila oocytes. The dimerization of Swallow depends on a 71-residue self-association domain in the center of the protein sequence, and is significantly stabilized by a binding interaction with dynein light chain (LC8). Here, we detail the use of solution-state nuclear magnetic resonance spectroscopy to characterize the structure of this self-association domain, thereby establishing that this domain forms a parallel coiled-coil and providing insight into how the stability of the dimerization interaction is regulated. | |||
Structural characterization of the self-association domain of swallow.,Loening NM, Barbar E Protein Sci. 2021 Feb 27. doi: 10.1002/pro.4055. PMID:33641207<ref>PMID:33641207</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6xor" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Drome]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Barbar E]] | [[Category: Barbar, E]] | ||
[[Category: Loening | [[Category: Loening, N M]] | ||
[[Category: Coiled coil]] | |||
[[Category: Rna binding protein]] | |||
[[Category: Self-association domain]] | |||
Revision as of 05:28, 28 April 2021
Structure of the Self-Association Domain of Swallow
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