Sandbox GGC6

Neurotrophin-4

spinqualitylabelsall models Neurotrophin-4 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Neurotrophin-4 (NT-4) belongs to a group of neuronal growth factors that influence nerve cell proliferation through selective and non-covalent interactions with the nerve growth factor receptor. Function NT-4 functions as a growth factor in many biological pathways and processes to induce neuronal proliferation. Biological Processes Positive regulation of neurotrophin TRK receptor signaling pathway: NT-4 functions as a ligand when binding to neurotrophin receptor tyrosine kinase NTRK2. Auto-phosphorylated NTRK2 dimers that are formed on tyrosine residues in receptor tail as a result of NT-4 binding. Adult locomotory behavior , neuron projection morphogenesis: generating projection structures of a neuron, ganglion mother cell fate determination, epidermis development, innervation, long term memory, chemical synaptic transmission modulation and nerve development, mechanoreceptor differentiation, negative regulation of neuron apoptotic process, and positive regulation of peptidyl-serine phosphorylation, nerve growth signaling pathway, and sensory organ boundary specification (taste bud development). Disease NT-4, along with other growth factors including neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) have all shown to be essential for survival of neurons. These growth factors have been associated with parts of the cerebrum including the frontal lobe and limbic system because of their involvement in neurological processes like behavior, learning, and memory. Availability and binding affinity are two factors that contribute to development of Alzheimer's disease and Huntington's disease, as well as neurodegenerative and psychiatric disorders. Structural highlights NT-4 is a homodimer; Its structure includes 2 Neurotrophin-4 factors bound with a chloride ion. This chloride ion is a ligand that binds to nerve growth factor receptors. NT-4 is 130 amino acids in length. N to C sequence N, 5'               C, 3' Copy and paste the following line where you want the scene link to appear (scroll down if needed) and edit the TextToBeDisplayed: Temperature Value min temp           max temp This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.