Postsynaptic density protein: Difference between revisions
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The combined SH3-GK structure of PSD-95 is characterized by an atypical hinge connecting the two. This compact fold allows regulatory proteins to bind at the hinge to switch from an intramolecular to intermolecular assembly. This switch could mediate PSD-95 oligomerization. <ref> DOI: 10.1073/pnas.1821775116 </ref> | The combined SH3-GK structure of PSD-95 is characterized by an atypical hinge connecting the two. This compact fold allows regulatory proteins to bind at the hinge to switch from an intramolecular to intermolecular assembly. This switch could mediate PSD-95 oligomerization. <ref> DOI: 10.1073/pnas.1821775116 </ref> | ||
Guanylate Kinase (GK): Normally guanylate kinase or GK acts to phosphorylate Guanine Diphosphate (GDP) by taking a phosphate from a Guanine Monophosphate (GMP); however, in the case of it acting as domain for PSD-95, it has a much different function. While a part of PSD-95, acts as an anchor point. This can be seen when it assists with the organization of the spindles that form during mitosis. It has also been observed to assist in the process of cell adhesion. | Guanylate Kinase (GK): Normally <scene name='88/881547/Guanylate_kinase/1'>guanylate kinase</scene> or GK acts to phosphorylate Guanine Diphosphate (GDP) by taking a phosphate from a Guanine Monophosphate (GMP); however, in the case of it acting as domain for PSD-95, it has a much different function. While a part of PSD-95, acts as an anchor point. This can be seen when it assists with the organization of the spindles that form during mitosis. It has also been observed to assist in the process of cell adhesion. | ||
FILAMENTS: In examining the PSD, an abundant number of filaments were discovered and categorized by dimension, shape, and their location on the PSD. A large number of filaments near the core are both straight and perpendicular to the PSD with dimensions of 5nm in diameter and 20nm long (Chen, 2008). Most of the vertical filaments were categorized as PSD-95, within the MAGUK family dimensions of 4nm in diameter and 20 nm long, and with their N terminal towards the post synaptic membrane (Chen, 2008). | FILAMENTS: In examining the PSD, an abundant number of filaments were discovered and categorized by dimension, shape, and their location on the PSD. A large number of filaments near the core are both straight and perpendicular to the PSD with dimensions of 5nm in diameter and 20nm long (Chen, 2008). Most of the vertical filaments were categorized as PSD-95, within the MAGUK family dimensions of 4nm in diameter and 20 nm long, and with their N terminal towards the post synaptic membrane (Chen, 2008). | ||
