1mpz: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[1mpz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Macrovipera_lebetina_obtusa Macrovipera lebetina obtusa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1MPZ FirstGlance]. <br>

<table><tr><td colspan='2'>[[1mpz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Macrovipera_lebetina_obtusa Macrovipera lebetina obtusa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MPZ FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1mpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mpz OCA], [~~http~~://pdbe.org/1mpz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1mpz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1mpz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1mpz ProSAT]</span></td></tr>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mpz OCA], [https://pdbe.org/1mpz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mpz RCSB], [https://www.ebi.ac.uk/pdbsum/1mpz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mpz ProSAT]</span></td></tr>

</table>

== Function ==

[[~~http~~://www.uniprot.org/uniprot/DIS_MACLO DIS_MACLO]] Is a potent and selective inhibitor of alpha-1/beta-1 (ITGA1/ITGB1) integrin. It blocks the adhesion of alpha-1/beta-1-expressing K562 cells to immobilized collagens IV and I with IC(50) of 2 and 0.5 nM, respectively. Potently inhibits angiogenesis in chicken and in mouse model and reduces tumor development by half. Is 25-fold less potent than viperistatin.<ref>PMID:12538900</ref> <ref>PMID:12727812</ref>

[[https://www.uniprot.org/uniprot/DIS_MACLO DIS_MACLO]] Is a potent and selective inhibitor of alpha-1/beta-1 (ITGA1/ITGB1) integrin. It blocks the adhesion of alpha-1/beta-1-expressing K562 cells to immobilized collagens IV and I with IC(50) of 2 and 0.5 nM, respectively. Potently inhibits angiogenesis in chicken and in mouse model and reduces tumor development by half. Is 25-fold less potent than viperistatin.<ref>PMID:12538900</ref> <ref>PMID:12727812</ref>

== Publication Abstract from PubMed ==

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 <StructureSection load='1mpz' size='340' side='right'caption='[[1mpz]], [[NMR_Ensembles_of_Models | 22 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1mpz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Macrovipera_lebetina_obtusa Macrovipera lebetina obtusa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MPZ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1mpz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Macrovipera_lebetina_obtusa Macrovipera lebetina obtusa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MPZ FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mpz OCA], [http://pdbe.org/1mpz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mpz RCSB], [http://www.ebi.ac.uk/pdbsum/1mpz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mpz ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mpz OCA], [https://pdbe.org/1mpz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mpz RCSB], [https://www.ebi.ac.uk/pdbsum/1mpz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mpz ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/DIS_MACLO DIS_MACLO]] Is a potent and selective inhibitor of alpha-1/beta-1 (ITGA1/ITGB1) integrin. It blocks the adhesion of alpha-1/beta-1-expressing K562 cells to immobilized collagens IV and I with IC(50) of 2 and 0.5 nM, respectively. Potently inhibits angiogenesis in chicken and in mouse model and reduces tumor development by half. Is 25-fold less potent than viperistatin.<ref>PMID:12538900</ref> <ref>PMID:12727812</ref>
+[[https://www.uniprot.org/uniprot/DIS_MACLO DIS_MACLO]] Is a potent and selective inhibitor of alpha-1/beta-1 (ITGA1/ITGB1) integrin. It blocks the adhesion of alpha-1/beta-1-expressing K562 cells to immobilized collagens IV and I with IC(50) of 2 and 0.5 nM, respectively. Potently inhibits angiogenesis in chicken and in mouse model and reduces tumor development by half. Is 25-fold less potent than viperistatin.<ref>PMID:12538900</ref> <ref>PMID:12727812</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==