2ef6: Difference between revisions
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<StructureSection load='2ef6' size='340' side='right'caption='[[2ef6]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='2ef6' size='340' side='right'caption='[[2ef6]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EF6 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand= | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ef6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef6 OCA], [https://pdbe.org/2ef6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ef6 RCSB], [https://www.ebi.ac.uk/pdbsum/2ef6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ef6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL]] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Canavalia gladiata]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Azevedo, W F.de]] | [[Category: Azevedo, W F.de]] | ||
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[[Category: Rocha, B A.M da]] | [[Category: Rocha, B A.M da]] | ||
[[Category: Souza, E P.de]] | [[Category: Souza, E P.de]] | ||
[[Category: Dimannoside]] | [[Category: Dimannoside]] | ||
[[Category: Lectin]] | [[Category: Lectin]] | ||
[[Category: Plant protein]] | [[Category: Plant protein]] | ||
[[Category: Seed]] | [[Category: Seed]] | ||
