2j8h

Structure of the immunoglobulin tandem repeat A168-A169 of titin

spinqualitylabelsall models 2j8h, resolution 1.99Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2j8h is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: GOL Related: 1bpv, 1g1c, 1nct, 1ncu, 1tit, 1tiu, 1tki, 1tnm, 1tnn, 1waa, 1ya5, 2a38, 2bk8, 2f8v Activity: Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Most of the structure of the giant muscle protein titin is formed by small modular domains. Many of them are predicted to be arranged in repeats with short linkers that may be key determinants of the peculiar elastic properties of titin. Here, we present the molecular structure of a tandem arrangement of two immunoglobulin-like domains, A168 and A169, located within the A-band segment of titin. The two domains are connected by a 17 residue long beta-strand and form a common interface. Based on these data, we establish general principles to estimate the amount of conformational flexibility of tandem domain motifs in titin. An unusual bulge within the second domain, A169, is directly involved into binding to a sarcomeric ligand, MURF-1, thus suggesting a dual role of this tandem for both the mechanical properties of titin and for sarcomeric signaling. Rigid conformation of an immunoglobulin domain tandem repeat in the A-band of the elastic muscle protein titin.,Muller S, Lange S, Gautel M, Wilmanns M J Mol Biol. 2007 Aug 10;371(2):469-80. Epub 2007 May 25. PMID:17574571 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Titin

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