2lg1: Difference between revisions
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==Solution structure of the human AKAP13 PH domain and stabilizing DH helix== | ==Solution structure of the human AKAP13 PH domain and stabilizing DH helix== | ||
<StructureSection load='2lg1' size='340' side='right' caption='[[2lg1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2lg1' size='340' side='right'caption='[[2lg1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2lg1]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2lg1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LG1 FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKAP13, BRX, HT31, LBC ([ | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKAP13, BRX, HT31, LBC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lg1 OCA], [https://pdbe.org/2lg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lg1 RCSB], [https://www.ebi.ac.uk/pdbsum/2lg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lg1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/AKP13_HUMAN AKP13_HUMAN]] Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element-specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions.<ref>PMID:11546812</ref> <ref>PMID:9627117</ref> <ref>PMID:9891067</ref> <ref>PMID:11579095</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[A-kinase anchor protein|A-kinase anchor protein]] | *[[A-kinase anchor protein 3D structures|A-kinase anchor protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Ball, L]] | [[Category: Ball, L]] | ||
[[Category: Lenoir, M]] | [[Category: Lenoir, M]] | ||
