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==NMR Solution Structure of MSP-P56S Domain/VAPB in DPC==
==NMR Solution Structure of MSP-P56S Domain/VAPB in DPC==
<StructureSection load='2mdk' size='340' side='right' caption='[[2mdk]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='2mdk' size='340' side='right'caption='[[2mdk]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2mdk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MDK FirstGlance]. <br>
<table><tr><td colspan='2'>[[2mdk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MDK FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VAPB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VAPB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mdk OCA], [http://pdbe.org/2mdk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mdk RCSB], [http://www.ebi.ac.uk/pdbsum/2mdk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mdk ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mdk OCA], [https://pdbe.org/2mdk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mdk RCSB], [https://www.ebi.ac.uk/pdbsum/2mdk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mdk ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/VAPB_HUMAN VAPB_HUMAN]] Adult-onset proximal spinal muscular atrophy, autosomal dominant;Amyotrophic lateral sclerosis. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  
[[https://www.uniprot.org/uniprot/VAPB_HUMAN VAPB_HUMAN]] Adult-onset proximal spinal muscular atrophy, autosomal dominant;Amyotrophic lateral sclerosis. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VAPB_HUMAN VAPB_HUMAN]] Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.<ref>PMID:16891305</ref> <ref>PMID:20940299</ref> <ref>PMID:22131369</ref>   
[[https://www.uniprot.org/uniprot/VAPB_HUMAN VAPB_HUMAN]] Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.<ref>PMID:16891305</ref> <ref>PMID:20940299</ref> <ref>PMID:22131369</ref>   
 
==See Also==
*[[Vesicle-associated membrane protein|Vesicle-associated membrane protein]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Lim, L]]
[[Category: Lim, L]]
[[Category: Qin, H]]
[[Category: Qin, H]]
Retrieved from "https://proteopedia.org/2mdk"