6zm0: Difference between revisions
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==Crystal structure of MreC from Pseudomonas aeruginosa== | ==Crystal structure of MreC from Pseudomonas aeruginosa== | ||
<StructureSection load='6zm0' size='340' side='right'caption='[[6zm0]]' scene=''> | <StructureSection load='6zm0' size='340' side='right'caption='[[6zm0]], [[Resolution|resolution]] 1.47Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZM0 FirstGlance]. <br> | <table><tr><td colspan='2'>[[6zm0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZM0 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zm0 OCA], [https://pdbe.org/6zm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zm0 RCSB], [https://www.ebi.ac.uk/pdbsum/6zm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zm0 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mreC, PA4480 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zm0 OCA], [https://pdbe.org/6zm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zm0 RCSB], [https://www.ebi.ac.uk/pdbsum/6zm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zm0 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/Q9HVU1_PSEAE Q9HVU1_PSEAE]] Involved in formation and maintenance of cell shape.[PIRNR:PIRNR038471] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The elongasome, or Rod system, is a protein complex that controls cell wall formation in rod-shaped bacteria. MreC is a membrane-associated elongasome component that co-localizes with the cytoskeletal element MreB and regulates the activity of cell wall biosynthesis enzymes, in a process that may be dependent on MreC self-association. Here, we use electron cryo-microscopy and X-ray crystallography to determine the structure of a self-associated form of MreC from Pseudomonas aeruginosa in atomic detail. MreC monomers interact in head-to-tail fashion. Longitudinal and lateral interfaces are essential for oligomerization in vitro, and a phylogenetic analysis of proteobacterial MreC sequences indicates the prevalence of the identified interfaces. Our results are consistent with a model where MreC's ability to alternate between self-association and interaction with the cell wall biosynthesis machinery plays a key role in the regulation of elongasome activity. | |||
Self-association of MreC as a regulatory signal in bacterial cell wall elongation.,Martins A, Contreras-Martel C, Janet-Maitre M, Miyachiro MM, Estrozi LF, Trindade DM, Malospirito CC, Rodrigues-Costa F, Imbert L, Job V, Schoehn G, Attree I, Dessen A Nat Commun. 2021 May 20;12(1):2987. doi: 10.1038/s41467-021-22957-9. PMID:34016967<ref>PMID:34016967</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6zm0" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Contreras-Martel C]] | [[Category: Pseae]] | ||
[[Category: Dessen A]] | [[Category: Contreras-Martel, C]] | ||
[[Category: Trindade | [[Category: Dessen, A]] | ||
[[Category: Trindade, D M]] | |||
[[Category: Cytoskeletal]] | |||
[[Category: Elongasome]] | |||
[[Category: Peptidoglycan]] | |||
[[Category: Rod-shape bacteria]] | |||
[[Category: Structural protein]] | |||
Revision as of 14:47, 2 June 2021
Crystal structure of MreC from Pseudomonas aeruginosa
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