7dp3: Difference between revisions
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==Human MCM8 N-terminal domain== | ==Human MCM8 N-terminal domain== | ||
<StructureSection load='7dp3' size='340' side='right'caption='[[7dp3]]' scene=''> | <StructureSection load='7dp3' size='340' side='right'caption='[[7dp3]], [[Resolution|resolution]] 2.55Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DP3 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7dp3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DP3 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dp3 OCA], [https://pdbe.org/7dp3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dp3 RCSB], [https://www.ebi.ac.uk/pdbsum/7dp3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dp3 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MCM8, C20orf154 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dp3 OCA], [https://pdbe.org/7dp3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dp3 RCSB], [https://www.ebi.ac.uk/pdbsum/7dp3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dp3 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[[https://www.uniprot.org/uniprot/MCM8_HUMAN MCM8_HUMAN]] NON RARE IN EUROPE: Primary ovarian failure. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/MCM8_HUMAN MCM8_HUMAN]] Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) (PubMed:15684404). Probably by regulating HR, plays a key role during gametogenesis (By similarity). Stabilizes MCM9 protein (PubMed:23401855, PubMed:26215093).[UniProtKB:Q9CWV1]<ref>PMID:15684404</ref> <ref>PMID:23401855</ref> <ref>PMID:26215093</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: DNA helicase]] | |||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Li J]] | [[Category: Li, J]] | ||
[[Category: Liu L]] | [[Category: Liu, L]] | ||
[[Category: Liu Y]] | [[Category: Liu, Y]] | ||
[[Category: Dna binding]] | |||
[[Category: Dna binding protein]] | |||
[[Category: Zinc finger]] | |||
