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==Solution structural studies of GTP:adenosylcobinamide-phosphate guanylyltransferase (CobY) from Methanocaldococcus jannaschii==
==Solution structural studies of GTP:adenosylcobinamide-phosphate guanylyltransferase (CobY) from Methanocaldococcus jannaschii==
<StructureSection load='2mzb' size='340' side='right' caption='[[2mzb]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2mzb' size='340' side='right'caption='[[2mzb]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2mzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Metja Metja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MZB FirstGlance]. <br>
<table><tr><td colspan='2'>[[2mzb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Metja Metja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MZB FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cobY, MJ1117 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243232 METJA])</td></tr>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cobY, MJ1117 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243232 METJA])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylcobinamide-phosphate_guanylyltransferase Adenosylcobinamide-phosphate guanylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.62 2.7.7.62] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Adenosylcobinamide-phosphate_guanylyltransferase Adenosylcobinamide-phosphate guanylyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.62 2.7.7.62] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mzb OCA], [http://pdbe.org/2mzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mzb RCSB], [http://www.ebi.ac.uk/pdbsum/2mzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mzb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mzb OCA], [https://pdbe.org/2mzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mzb RCSB], [https://www.ebi.ac.uk/pdbsum/2mzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mzb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/COBY_METJA COBY_METJA]] Guanylyltransferase that catalyzes the synthesis of adenosylcobinamide-GDP (AdoCbi-GDP) from adenosylcobinamide-phosphate (AdoCbi-P) and GTP. Is involved in adenosylcobalamin biosynthesis. Binds one GTP per dimer. Can not use other NTPs or GDP. Does not display AdoCbi kinase activity. Is also able to catalyze the condensation of 2-phospho-L-lactate (LP) with GTP in vitro to form PPi and (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), but is much less efficient than CofC, the presumed enzyme catalyzing this reaction in vivo.<ref>PMID:18260642</ref> <ref>PMID:19489548</ref>   
[[https://www.uniprot.org/uniprot/COBY_METJA COBY_METJA]] Guanylyltransferase that catalyzes the synthesis of adenosylcobinamide-GDP (AdoCbi-GDP) from adenosylcobinamide-phosphate (AdoCbi-P) and GTP. Is involved in adenosylcobalamin biosynthesis. Binds one GTP per dimer. Can not use other NTPs or GDP. Does not display AdoCbi kinase activity. Is also able to catalyze the condensation of 2-phospho-L-lactate (LP) with GTP in vitro to form PPi and (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), but is much less efficient than CofC, the presumed enzyme catalyzing this reaction in vivo.<ref>PMID:18260642</ref> <ref>PMID:19489548</ref>   
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Adenosylcobinamide-phosphate guanylyltransferase]]
[[Category: Adenosylcobinamide-phosphate guanylyltransferase]]
[[Category: Large Structures]]
[[Category: Metja]]
[[Category: Metja]]
[[Category: Escalante-Semerena, J C]]
[[Category: Escalante-Semerena, J C]]
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