Chaperonin: Difference between revisions

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<StructureSection load='' size='350' side='right' caption='E. coli GroEL (green)/GroES (magenta) complex with ADP, AlF3, Mg+2 and K+ ions (PDB entry [[1pcq]])' scene='44/445432/Cv/1'>
<StructureSection load='' size='350' side='right' caption='E. coli GroEL (green)/GroES (magenta) complex with ADP, AlF3, Mg+2 and K+ ions (PDB entry [[1pcq]])' scene='44/445432/Cv/1'>
[[Image:1pcq.png|left|200px|thumb|Crystal Structure of Chaperonin, [[1pcq]]]]
[[Image:1pcq.png|left|200px|thumb|Crystal Structure of Chaperonin, [[1pcq]]]]
'''Chaperonins''' (CPN) are oligomeric proteins that mediate the folding of polypeptide chains.  '''Group I CPN''' are found in bacteria, chloroplasts and mitochondria.  For an introductory overview, see [http://en.wikipedia.org/wiki/Chaperonins Chaperonins in Wikipedia].
'''Chaperonins''' (Cpn) are oligomeric proteins that mediate the folding of polypeptide chains.  '''Group I CPN''' are found in bacteria, chloroplasts and mitochondria.  For an introductory overview, see [http://en.wikipedia.org/wiki/Chaperonins Chaperonins in Wikipedia].


The most characterized CPN are in the GroEL/GroES complex from ''Escherichia coli'' and CPN60/CPN10 from ''Thermus thermophilus''.<ref>PMID:18987317</ref>  The larger subunit (GroEL, CPN60) contains 3 domains: apical, intermediate and equatorial domain.  The apical domain is the one which binds the polypeptide substrate. The equatorial domains binds the nucleotide.  '''Group II CPNs''' are found in eukaryotic cytosol and archaea.  '''Thermosome''' is a CPN complex found in archaea.<ref>PMID:9546398</ref>  '''CCT''' or '''TRiC''' is a CPN complex found in eukarya.<ref>PMID:22503819</ref>
The most characterized Cpn are in the GroEL/GroES complex from ''Escherichia coli'' and Cpn60/Cpn10 from ''Thermus thermophilus''.<ref>PMID:18987317</ref>  The larger subunit (GroEL, Cpn60) contains 3 domains: apical, intermediate and equatorial domain.  The apical domain is the one which binds the polypeptide substrate. The equatorial domains binds the nucleotide.  '''Group II Cpns''' are found in eukaryotic cytosol and archaea.  '''Thermosome''' is a Cpn complex found in archaea.<ref>PMID:9546398</ref>  '''CCT''' or '''TRiC''' is a Cpn complex found in eukarya.<ref>PMID:22503819</ref>
*<scene name='44/445432/Cv/2'>E. coli GroEL/GroES complex</scene> (GroEL in green, GroES in magenta, PDB entry [[1pcq]]).
*<scene name='44/445432/Cv/2'>E. coli GroEL/GroES complex</scene> (GroEL in green, GroES in magenta, PDB entry [[1pcq]]).
*<scene name='44/445432/Cv/3'>GroEL/GroES complex with ADP, AlF3, Mg+2 and K+ ions</scene>.  
*<scene name='44/445432/Cv/3'>GroEL/GroES complex with ADP, AlF3, Mg+2 and K+ ions</scene>.  
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