2nn2: Difference between revisions

Line 1:

==Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator==

== Structural highlights ==

<table><tr><td colspan='2'>[[2nn2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NN2 OCA]. For a guided tour on the structure components use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2NN2 FirstGlance].

<table><tr><td colspan='2'>[[2nn2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NN2 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=2NN2 FirstGlance].

</td></tr><tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">ZBTB7A, FBI1, LRF, ZBTB7 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

</td></tr><tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">ZBTB7A, FBI1, LRF, ZBTB7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2nn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nn2 OCA], [~~http~~://pdbe.org/2nn2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2nn2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2nn2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2nn2 ProSAT]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=2nn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nn2 OCA], [https://pdbe.org/2nn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nn2 RCSB], [https://www.ebi.ac.uk/pdbsum/2nn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nn2 ProSAT]</td></tr>

</table>

== Function ==

[[~~http~~://www.uniprot.org/uniprot/ZBT7A_HUMAN ZBT7A_HUMAN]] Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity).

[[https://www.uniprot.org/uniprot/ZBT7A_HUMAN ZBT7A_HUMAN]] Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity).

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

Line 33:

</StructureSection>

[[Category: Human]]

[[Category: Large Structures]]

[[Category: Chen, L]]

[[Category: Prive, G G]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
 ==Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator==
-<StructureSection load='2nn2' size='340' side='right' caption='[[2nn2]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+<StructureSection load='2nn2' size='340' side='right'caption='[[2nn2]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2nn2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NN2 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2nn2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NN2 FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZBTB7A, FBI1, LRF, ZBTB7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZBTB7A, FBI1, LRF, ZBTB7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nn2 OCA], [http://pdbe.org/2nn2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nn2 RCSB], [http://www.ebi.ac.uk/pdbsum/2nn2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nn2 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nn2 OCA], [https://pdbe.org/2nn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nn2 RCSB], [https://www.ebi.ac.uk/pdbsum/2nn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nn2 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/ZBT7A_HUMAN ZBT7A_HUMAN]] Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity).
+[[https://www.uniprot.org/uniprot/ZBT7A_HUMAN ZBT7A_HUMAN]] Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 33: / Line 33: @@
 </StructureSection>
 [[Category: Human]]
+[[Category: Large Structures]]
 [[Category: Chen, L]]
 [[Category: Prive, G G]]