2obd: Difference between revisions

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==Crystal Structure of Cholesteryl Ester Transfer Protein==
==Crystal Structure of Cholesteryl Ester Transfer Protein==
<StructureSection load='2obd' size='340' side='right' caption='[[2obd]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='2obd' size='340' side='right'caption='[[2obd]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2obd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OBD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OBD FirstGlance]. <br>
<table><tr><td colspan='2'>[[2obd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OBD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=2OB:CHOLESTERYL+OLEATE'>2OB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PCW:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PCW</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=2OB:CHOLESTERYL+OLEATE'>2OB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=PCW:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PCW</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CETP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CETP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2obd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2obd OCA], [http://pdbe.org/2obd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2obd RCSB], [http://www.ebi.ac.uk/pdbsum/2obd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2obd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2obd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2obd OCA], [https://pdbe.org/2obd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2obd RCSB], [https://www.ebi.ac.uk/pdbsum/2obd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2obd ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/CETP_HUMAN CETP_HUMAN]] Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1) [MIM:[http://omim.org/entry/143470 143470]]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).<ref>PMID:2215607</ref> <ref>PMID:8408659</ref> <ref>PMID:12091484</ref>   
[[https://www.uniprot.org/uniprot/CETP_HUMAN CETP_HUMAN]] Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1) [MIM:[https://omim.org/entry/143470 143470]]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).<ref>PMID:2215607</ref> <ref>PMID:8408659</ref> <ref>PMID:12091484</ref>   
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CETP_HUMAN CETP_HUMAN]] Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol.  
[[https://www.uniprot.org/uniprot/CETP_HUMAN CETP_HUMAN]] Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol.  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ob/2obd_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ob/2obd_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Qiu, X]]
[[Category: Qiu, X]]
[[Category: Cholesteryl ester]]
[[Category: Cholesteryl ester]]
[[Category: Lipid transfer protein]]
[[Category: Lipid transfer protein]]
[[Category: Lipid transport]]
[[Category: Lipid transport]]
Retrieved from "https://proteopedia.org/2obd"