7n2b: Difference between revisions
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==A DARPin semi-rigidly fused to the 3TEL crystallization chaperone== | ==A DARPin semi-rigidly fused to the 3TEL crystallization chaperone== | ||
<StructureSection load='7n2b' size='340' side='right'caption='[[7n2b]]' scene=''> | <StructureSection load='7n2b' size='340' side='right'caption='[[7n2b]], [[Resolution|resolution]] 3.22Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N2B FirstGlance]. <br> | <table><tr><td colspan='2'>[[7n2b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N2B FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n2b OCA], [https://pdbe.org/7n2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n2b RCSB], [https://www.ebi.ac.uk/pdbsum/7n2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n2b ProSAT]</span></td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ETV6, TEL, TEL1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n2b OCA], [https://pdbe.org/7n2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n2b RCSB], [https://www.ebi.ac.uk/pdbsum/7n2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n2b ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[[https://www.uniprot.org/uniprot/ETV6_HUMAN ETV6_HUMAN]] Note=A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with PDGFRB. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML).<ref>PMID:12203785</ref> Note=Chromosomal aberrations involving ETV6 are found in a form of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with MN1; translocation t(4;12)(q12;p13) with CHIC2.<ref>PMID:7761424</ref> <ref>PMID:7780150</ref> <ref>PMID:15806161</ref> Note=Chromosomal aberrations involving ETV6 are found in childhood acute lymphoblastic leukemia (ALL). Translocations t(12;21)(p12;q22) and t(12;21)(p13;q22) with RUNX1/AML1. Note=A chromosomal aberration involving ETV6 is found in a form of pre-B acute myeloid leukemia. Translocation t(9;12)(p24;p13) with JAK2. Note=A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS) with basophilia. Translocation t(5;12)(q31;p13) with ACSL6. Note=A chromosomal aberration involving ETV6 is found in acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ACSL6. Note=A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS). Translocation t(1;12)(p36.1;p13) with MDS2. Defects in ETV6 are a cause of myeloproliferative disorder chronic with eosinophilia (MPE) [MIM:[https://omim.org/entry/131440 131440]]. A hematologic disorder characterized by malignant eosinophils proliferation. Note=A chromosomal aberration involving ETV6 is found in many instances of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;12) with PDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein. Defects in ETV6 are a cause of acute myelogenous leukemia (AML) [MIM:[https://omim.org/entry/601626 601626]]. AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development.<ref>PMID:7761424</ref> <ref>PMID:7780150</ref> <ref>PMID:15806161</ref> Note=A chromosomal aberration involving ETV6 is found in acute lymphoblastic leukemia. Translocation t(9;12)(p13;p13) with PAX5. | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/ETV6_HUMAN ETV6_HUMAN]] Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bunn D]] | [[Category: Bunn, D]] | ||
[[Category: | [[Category: Doukov, T]] | ||
[[Category: Gajjar P]] | [[Category: Gajjar, P]] | ||
[[Category: Moody | [[Category: Moody, J D]] | ||
[[Category: Sarath | [[Category: Nawarathange, S D.Sarath]] | ||
[[Category: Stewart C]] | [[Category: Stewart, C]] | ||
[[Category: Designed ankyrin repeat protein]] | |||
[[Category: Polymer]] | |||
[[Category: Protein binding]] | |||
[[Category: Sterile alpha motif]] | |||
[[Category: Translocation ets leukemia]] | |||
Revision as of 15:00, 17 June 2021
A DARPin semi-rigidly fused to the 3TEL crystallization chaperone
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