2q1f: Difference between revisions

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==Crystal structure of chondroitin sulfate lyase abc from bacteroides thetaiotaomicron wal2926==
==Crystal structure of chondroitin sulfate lyase abc from bacteroides thetaiotaomicron wal2926==
<StructureSection load='2q1f' size='340' side='right' caption='[[2q1f]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
<StructureSection load='2q1f' size='340' side='right'caption='[[2q1f]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2q1f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_thetaiotaomicron"_distaso_1912 "bacillus thetaiotaomicron" distaso 1912]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q1F FirstGlance]. <br>
<table><tr><td colspan='2'>[[2q1f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_thetaiotaomicron"_distaso_1912 "bacillus thetaiotaomicron" distaso 1912]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q1F FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cslABC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=818 "Bacillus thetaiotaomicron" Distaso 1912])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cslABC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=818 "Bacillus thetaiotaomicron" Distaso 1912])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chondroitin-sulfate-ABC_exolyase Chondroitin-sulfate-ABC exolyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.21 4.2.2.21] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Chondroitin-sulfate-ABC_exolyase Chondroitin-sulfate-ABC exolyase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.21 4.2.2.21] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q1f OCA], [http://pdbe.org/2q1f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q1f RCSB], [http://www.ebi.ac.uk/pdbsum/2q1f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2q1f ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q1f OCA], [https://pdbe.org/2q1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q1f RCSB], [https://www.ebi.ac.uk/pdbsum/2q1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q1f ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CABC2_BACTN CABC2_BACTN]] Broad-specificity glycosaminoglycan lyase, which acts in an exolytic fashion degrading chondroitin sulfates and dermatan sulfate to yield only disaccharide products. Has a preference for chondroitin 4-sulfate over chondroitin 6-sulfate. Has extremely low activity against hyaluronic acid. Is not active against acharan sulfate, heparin or heparan sulfate.[UniProtKB:C5G6D7]<ref>PMID:6630153</ref>   
[[https://www.uniprot.org/uniprot/CABC2_BACTN CABC2_BACTN]] Broad-specificity glycosaminoglycan lyase, which acts in an exolytic fashion degrading chondroitin sulfates and dermatan sulfate to yield only disaccharide products. Has a preference for chondroitin 4-sulfate over chondroitin 6-sulfate. Has extremely low activity against hyaluronic acid. Is not active against acharan sulfate, heparin or heparan sulfate.[UniProtKB:C5G6D7]<ref>PMID:6630153</ref>   
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q1/2q1f_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q1/2q1f_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Bacillus thetaiotaomicron distaso 1912]]
[[Category: Bacillus thetaiotaomicron distaso 1912]]
[[Category: Chondroitin-sulfate-ABC exolyase]]
[[Category: Chondroitin-sulfate-ABC exolyase]]
[[Category: Large Structures]]
[[Category: Cygler, M]]
[[Category: Cygler, M]]
[[Category: Shaya, D]]
[[Category: Shaya, D]]
[[Category: Alpha plus beta]]
[[Category: Alpha plus beta]]
[[Category: Lyase]]
[[Category: Lyase]]
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