1b86: Difference between revisions
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New page: left|200px<br /> <applet load="1b86" size="450" color="white" frame="true" align="right" spinBox="true" caption="1b86, resolution 2.5Å" /> '''HUMAN DEOXYHAEMOGLOB... |
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==Overview== | ==Overview== | ||
The haemoglobin-2,3-diphosphoglycerate complex structure has been solved, at 2.5 A resolution using crystals grown from low-salt solutions. The, results show some important differences with the precedent, haemoglobin-2,3-diphosphoglycerate high-salt structure solved by Arnone., First, we observe a loss of symmetry in the binding site, secondly both of, the lysine residues 82 beta interact with 2,3-diphosphoglycerate at the, same time, each making two contacts. This level of interaction is in, agreement with the functional behaviour of natural haemoglobin mutants, with mutations at the 2,3-diphosphoglycerate binding site. | The haemoglobin-2,3-diphosphoglycerate complex structure has been solved, at 2.5 A resolution using crystals grown from low-salt solutions. The, results show some important differences with the precedent, haemoglobin-2,3-diphosphoglycerate high-salt structure solved by Arnone., First, we observe a loss of symmetry in the binding site, secondly both of, the lysine residues 82 beta interact with 2,3-diphosphoglycerate at the, same time, each making two contacts. This level of interaction is in, agreement with the functional behaviour of natural haemoglobin mutants, with mutations at the 2,3-diphosphoglycerate binding site. | ||
==Disease== | |||
Known diseases associated with this structure: Erythremias, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141800 141800]], Erythremias, beta- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Erythrocytosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141850 141850]], HPFH, deletion type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Heinz body anemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141850 141850]], Heinz body anemias, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141800 141800]], Heinz body anemias, beta- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Hemoglobin H disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141850 141850]], Hypochromic microcytic anemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141850 141850]], Methemoglobinemias, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141800 141800]], Methemoglobinemias, beta- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Sickle cell anemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Thalassemia, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141850 141850]], Thalassemia-beta, dominant inclusion-body OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Thalassemias, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141800 141800]], Thalassemias, beta- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]] | |||
==About this Structure== | ==About this Structure== | ||
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[[Category: haemoglobin]] | [[Category: haemoglobin]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:07:09 2007'' | ||
